The Department of Pharmacy in the School of Life Science and allied professionals, in its quest to continually contribute to the well being of Malawians in general, has embarked on a number of research activities aimed at developing new medicines for existing diseases. One of those existing diseases is Tuberculosis (TB). Currently some of the TB strains found in Malawi are resistant to the common medicines that were developed to treat this disease (MDRTB). As such there is need to develop the next generation of medicines. We have reason to believe that some of the structures in our data library offer another angle to developing such new drugs. The World Academy of Sciences (TWAS) have given us a grant for this work and we are now looking for innovative and creating individuals to work on this project. Individuals will be enrolledinto Kamuzu University of Health Sciences as a Masters student and must meet the requirements for a masters student. Using the understanding of chemical synthesis and physcochemical properties of drugs, students will modify such structures to create new structures which shall be tested for potency against MDRTB. Those with interest and or experience in organic synthesis and medicinal chemistry may find this particularly interesting. Students will have 18 months to create new structures, test them and optimise them. This is a fantacstic opportunity. Female students are particularly encouraged to apply. An MPhil degree is a Masters by research. Thus it is expected that students are mature, organised and able to conduct research with minimal supervision.